Publications by Radhika Subramanian

2025 Publications

Non-canonical CDK6 activity promotes cilia disassembly by suppressing axoneme polyglutamylation

Kai He, Xiaobo Sun, Chuan Chen, San Luc, Jielu Hao Robichaud, Yingyi Zhang,Yan Huang, Biyun Ji, Pei-I Ku, Radhika Subramanian, Kun Ling, Jinghua Hu. [2025] J Cell Biol (2025) 224 (2): e202405170.

2024 Publications

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade

Madison F. Walker*, Jingyi Zhang*, William Steiner*, Pei-I Ku*, Ju-Fen Zhu,Zachary, Michaelson, Yu-Chen, Yen, Annabel Lee, Alyssa B. Long, Mattie J. Casey, Abhishek Poddar, Isaac B. Nelson, Corvin D. Arveseth, Falko Nagel, Ryan Clough, Sarah LaPotin, Kristen M. Kwan, Stefan Schulz, Rodney A. Stewart, John J. G. Tesmer, Tamara Caspary, Radhika Subramanian*, Xuecai Ge*, Benjamin R. Myers*. [2024] PLoS Biol. 2024 Aug 13;22(8):e3002685.

Torques within and outside the human spindle balance twist at anaphase

Torques within and outside the human spindle balance twist at anaphase
Lila Neahring, Nathan H. Cho, Yifei He, Gaoxiang Liu, Jonathan Fernandes, Caleb J. Rux, Konstantinos Nakos, Radhika Subramanian, Srigokul Upadhyayula, Ahmet Yildiz, Sophie Dumont. [2024] J Cell Biol (2024) 223 (9): e202312046.

Modularity of PRC1 Composition and Chromatin Interaction define Condensate Properties

Stefan Niekamp, Sharon K. Marr, Theresa A. Oei, Radhika Subramanian*, Robert E. Kingston*. [2024] Volume 84, Issue 9, 2 May 2024, Pages 1651-1666.e12

Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast

Daniel J. Barrero, Sithara S. Wijeratne, Xiaowei Zhao, Grace F. Cunningham, Rui Yan, Christian R. Nelson, Yasuhiro Arimura, Hironori Funabiki, Charles L. Asbury, Zhiheng Yu, Radhika Subramanian, Sue Biggins. [2024] Curr Biol. 2024 Sep 9;34(17):3881-3893.e5.

Cytoskeleton crosstalk: Casting stable actin bundles with dynamic microtubule molds

Farah Haque and Radhika Subramanian*. [2024] Current Biology Volume 34, Issue 2, 22 January 2024, Pages R72-R74

2023 Publications

Interplay of self-organization of microtubule asters and crosslinking protein condensates

Sahu S, Chauhan P, Lumen E, Moody K, Peddireddy K, Mani N, Subramanian R, Robertson-Anderson R, Wolfe AJ, Ross JL. [2023] PNAS Nexus, Volume 2, Issue 7, July 2023, pgad231

2022 Publications

Active microphase separation in mixtures of microtubules and tip-accumulating molecular motors

Lemma B, Mitchell NP, Subramanian R, Needleman DJ, Dogic Z. [2022] Physical Review X 12, 031006.

Motor guidance by long-range communication through the microtubule highway

Wijeratne SS, Fiorenza SA, Subramanian R*, Betterton MD*. [2022] *co-corresponding/co-senior author. Proc Natl Acad Sci USA. 2022 July 7;119 (28) e2120193119.

Cytoskeletal regulation of a transcription factor by DNA mimicry via coiled-coil interactions

Haque F, Freniere C, Ye Q, Mani N, Wilson-Kubalek LM, Ku Pi-I, Milligan RA, Subramanian, R*. [2022] Nat Cell Biol 24, 1088–1098 (2022).

Atomic Force Microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays

Wijeratne SS, Marchan MF, Tresback JS, Subramanian R*. [2022] Proc Natl Acad Sci USA. 2022 Feb 1;119(5):e2115708119.

Engineering stability, longevity, and miscibility of microtubule-based active fluids

Chandrakar P, Berezney J, Lemma B, Hishamunda B, Berry A, Wu K-T, Subramanian R, Chung J, Needleman DJ, Gelles J, Dogic, Z. [2022] Soft Matter, 2022,18, 1825-1835

Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy

Mani N, Marchan M F, Subramanian R*. [2022] J. Vis. Exp. (180), e63377

2021 Publications

The tail wags the tubulin

Mani N and Subramanian R*. [2021] Developmental Cell, Volume 56, Issue 14, 26 July 2021, pages 2007-2009. (preview)

Micron-scale geometrical features of microtubules as regulators of microtubule organization

Mani N, Wijeratne S and Subramanian R*. [2021] eLife, Jun 11; 10:e63880.
doi: 10.7554/eLife.63880.

Differential Regulation of Single Microtubules and Cross-linked Bundles by a Minimal Three-Protein Module

Mani N, Jiang S, Neary AE, Wijeratne S and Subramanian R*. [2021] Nat Chem Biol 17, 964–974 (2021)

2019 Publications

Mitotic spindle: From living and synthetic systems to theory

Simunic J*, Subramanian R*. [2019] Journal of Cell Science. 2019 Sep 2;132(17). Meeting report.

Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary

Jiang S, Mani N, Wilson-Kubalek EM, Ku PI, Milligan RA, Subramanian R*.
Kinesin Kif7. [2019] Dev. Cell 2019 Jun 03; 49(5):711-730.e8

2018 Publications

Composition, Structure, and Function of the Eukaryotic Flagellum Distal Tip

Croft J, Zabeo D, Subramanian R and Hoog J. [2018] Essays in Biochemistry. 2018 Nov 20 pii: EBC20180032

2015 Publications

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors

Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, Hideshima T, Majireck MM, Hussain MM, Singh S, Quiroz R, Iaconelli J, Karmacharya R, Tolliday NJ, Clemons PA, Moore MAS, Stern AM, Shamji AF, Ebert BL, Golub TR, Raje NS, Scadden DT, Schreiber SL. [2015] Cell Rep 2015 Feb 10; 10(5):755-770

2014 Publications

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

He M, Subramanian R, Bangs F, Omelchenko T, Liem KF, Kapoor TM, Anderson KV. [2014] Nat. Cell Biol. 2014 Jul; 16(7):663-72

2013 Publications

Slipping past the spindle assembly checkpoint

Subramanian R, Kapoor TM. [2013] Nat. Cell Biol. 2013 Nov; 15(11):1261-3

Marking and measuring single microtubules by PRC1 and kinesin-4

Subramanian R, Ti SC, Tan L, Darst SA, Kapoor TM. [2013] Cell 2013 Jul 18; 154(2):377-90

2012 Publications

Building complexity: insights into self-organized assembly of microtubule-based architectures

Subramanian R, Kapoor TM. [2012] Dev. Cell 2012 Nov 13; 23(5):874-85

2010 Publications

Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein

Subramanian R, Wilson-Kubalek EM, Arthur CP, Bick MJ, Campbell EA, Darst SA, Milligan RA, Kapoor TM. [2010] Cell 2010 Aug 6; 142(3):433-43

2009 Publications

Meiotic spindle self-organization: one plus one equals only one

Subramanian R, Kapoor T. [2009] Curr. Biol. 2009 Apr 14; 19(7):R290-2

2007 Publications

Two distinct modes of processive kinesin movement in mixtures of ATP and AMP-PNP

Subramanian R, Gelles J. [2007] J. Gen. Physiol. 2007 Nov; 130(5):445-55